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To limit your PubMed search to the best evidence-producing studies - use Clinical Queries. This specialized search is intended for clinicians and has built-in search filters. After completing a topic search, you can also use the Limits tab and choose types of articles such as Meta-Analysis, Randomized Controlled Trial, Practice Guideline, etc.
After you have run a search, click on the EBM tab. You will then be able to limit your results to Cochrane Reviews, Systematic Reviews, Meta-Analysis, Controlled Clinical Trials, or Randomized Controlled Trials.
To limit your search to evidence-based literature, scroll down the search page and either select appropriate EBM type studies (SR, controlled trial, etc.) from the Publication Type box OR in the Special Interest box, select Evidence Based Practice OR click Evidence-Based Practice box on the right hand column.