October 1773: Rush co-writes, with other members of the Philadelphia “Sons of Liberty” the anti-tea-tax broadside which is published in Philadelphia and Boston as the justification for what becomes the Boston Tea Party on December 16, 1773.
In 1774, Rush, along with other physicians, established the Society for Inoculating the poorto help stop the spread of smallpox (The Sutton Method).
February 1774: Rush gave his first oration at the Philosophical Society.
August 29, 1774: Rush meets John Adams and the Massachusetts delegation to the First Continental Congress, outside of Philadelphia and gives them advice Adams considers impertinent at the time but later decides was brilliant.
During First Continental Congress, Rush meets and gets to know George Washington, Samuel Adams, Patrick Henry (who he inoculated), and others.
February 1775: Rush meets "a certain Thomas Paine" who he encourages to write what will become Common Sense (which Rush edited and got published).
May 1775: Second Continental Congress in Philadelphia where Rush meets Thomas Jefferson.
Fall 1775: Rush begins writing love letters to Julia Stockton the sixteen-year-old daughter of Princeton lawyer Richard Stockton and his writer wife the former Annis Boudinot.
In 1773, Rush met a French Quaker abolitionist named Anthony Benezet. Benezet chatted with Rush about taxing the importation of new slaves heavily so that the practice of slavery would be prohibited. He had Rush write the pamphlet that same year.